Efficacy of Bictegravir​/​Emtricitabine​/​Tenofovir Alafenamide in Participants With Preexisting Primary Integrase Inhibitor Resistance

Researchers examined virologic outcomes throughout 48 weeks of treatment with of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in patients who have preexisting primary integrase strand transfer inhibitor resistance (INSTI-R). The preexisting INSTI-R was assessed retrospectively from 7 B/F/TAF studies by historical genotypes and/or RNA or DNA sequencing at baseline. Measurement of viral loads was completed at all visits. Of 1907 participants, preexisting primary INSTI-R substitutions were found in 20, who were mainly Black, male, had HIV-1 subtype B, and baseline median CD4 counts of 594 cells/mm. The median age was 52 years of age. The group who had primary INSTI-R either achieved or maintained virologic suppression throughout 48 weeks of therapy with B/F/TAF.

Reference: D’Antoni ML, Andreatta K, Acosta R, et al. Brief Report: Bictegravir/Emtricitabine/Tenofovir Alafenamide Efficacy in Participants With Preexisting Primary Integrase Inhibitor Resistance Through 48 Weeks of Phase 3 Clinical Trials. J Acquir Immune Defic Syndr. 2022;89(4):433-440. doi:10.1097/QAI.0000000000002888
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