Assessing Outcomes of Patients With and Without HIV Hospitalized With COVID-19 in England

Researchers aimed to assess the clinical outcomes of patients with and without HIV who were hospitalized with COVID-19 during the beginning stages of the pandemic. Patients with HIV were matched to HIV-negative patients who were admitted from February 1, 2020, to May 31, 2020 up to a ratio of 3:1 by hospital site, SARS-CoV-2 test date ± 7 days, age ± 5 years, gender, and index of multiple deprivation decile ± 1. There were a total of 68 patients with HIV and 181 HIV-negative comparators included in the study.

Those with HIV were more likely to be of a black, Asian, or minority ethnic background (75.0% vs 48.6%, p =.0002), have a higher median clinical frailty score (3 × interquartile range [IQR]: 2–5 vs, 2 × IQR: 1–4, p = .0069), and to have a non-considerably higher proportion of active malignancy (14.4% vs 9.9%, p =.29). Overall, the study highlights the importance of an appropriate comparison cohort when examining outcomes in patients with HIV who are hospitalized with COVID-19.


Lee MJ, Snell LB, Douthwaite ST, et al. Clinical outcomes of patients with and without HIV hospitalized with COVID-19 in England during the early stages of the pandemic: a matched retrospective multi-centre analysis (RECEDE-C19 study). HIV Med. 2022;23(2):121-133. doi:10.1111/hiv.13174